Navigating the neuroinflammatory network: insights from diverse cell models

CASTELLANOS, LIBIA CATALINA SALINAS; MONTES, MAYRA MICAELA; MALNATI, GEORGINA ORIANA MINGOLO; WEISSMANN, CARINA

In vitro models

Springer Nature

Lugar: Basel; Año: 2024

In this Highlights article, we present insights into the use of simple cell lines in neuroinflammation research, highlightingkey findings from our recent investigations. Simple cell lines, including HEK, PC12, SHSY5Y, and N2a cells, provide valu-able insights into critical signaling pathways and hidden facets of the neuroinflammatory landscape. Focusing on specificoutcomes, including the impact of interleukin-6 (IL-6) and acid-sensing ion channels (ASIC1a), the study sheds light onneuroinflammatory processes. Results showcase the potential of diverse cell models in identifying specific molecules and offera multidimensional perspective on the intricate neuroinflammatory network, paving the way for therapeutic interventions.