INVESTIGADORES
DE LA FUENTE Veronica
congresos y reuniones científicas
Título:
MIFEPRISTONE IMPROVES THE EFFECT OF CHEMOTHERAPY ON EXPERIMENTAL BRAIN METASTASIS INHIBITING THE EXPRESSION OF P-GLYCOPROTEIN OF THE BLOOD BRAIN BARRIER
Autor/es:
RUBIN, A; CARABIAS P; DE LA FUENTE V; ELÍA A; TRONCOSO MF; LANARI C; ROJAS P
Lugar:
Virtual
Reunión:
Congreso; Reunión Anual de Sociedades de Biociencia SAIC.SAI.SAFIS 2020; 2020
Institución organizadora:
SAIC, SAI, SAFIS
Resumen:
The presence of multidrug resistance efflux transporters, such as the P-glycoprotein (Pgp) on the blood brain barrier (BBB), limits the efficacy of chemotherapeutic agents on brain tumors or metastasis. The antiprogestin mifepristone (MFP) is known to inhibit Pgp activity on tumor cells. The murine mammary carcinoma C4-2-HI, whose growth is not inhibited by MFP treatment and the human triple negative MDA-231Br cells were injected into the brain as previously described. Both models are sensitive to Doxorubicin (doxo) treatment. However, when low doxo doses were used, a significant decrease in tumor size was only observed in mice treated with MFP and doxo (p
