NF-kappa B is required for memory reconsolidation

FREUDENTHAL R; BOCCIA M; DE LA FUENTE V; ACOSTA G; BLAKE M; BARATTI C; ROMANO A

Florianópolis, Brasil

Workshop; 13th International Summer School in Behavioral Neurogenetics; 2006

Universidad Federal de Santa Catarina

Several studies support that stored memories undergo a new period of consolidation after retrieval. It is not known whether this process, termed reconsolidation, requires the same transcriptional mechanisms involved in consolidation. Increasing evidence supports the participation of the model of Chasmagnathus B in memory. Recently we found in the crab κ transcription factor NFB is activated specifically by retrieval and that this κ associative contextual memory that NFB after κ activation is required for memory reconsolidation. Here we found that the inhibition of NFmemory reactivation impaired retention in inhibitory avoidance in mice. Two independent strategies were used: the i.c.v. administration of sulfasalazine, an inhibitor of IKK the kinase that activates B consisting in a double κ B decoy, a direct inhibitor of NF- κ B and i.c.v. administration of κ NFB consensus sequence together with the κ strand DNA oligonucleotide that contains the administration of a control mutated sequence. Both treatments were applied immediately after the first testing session 48 hs after one trial training. Five subsequent tests with 24 hs interval reveled memory impairment. These data support the role of this transcription factor as an evolutionary conserved molecular mechanism involved in both consolidation and reconsolidation.