Mechanism of Coenzyme q10 in improving ovarian function in obesity

SARRIBLE GISELA; BAZZANO MARÍA VICTORIA; ELIA EVELIN MARIEL

CABA

Congreso; Reunión Anual de Biociencia 2019; 2019

Obesity has grown to epidemic proportions worldwide. It is associated with multiple adverse reproductive outcomes such as infertility and ovulation dysfunction. Coenzyme Q10 (CoQ10) is applied for the treatment of several pathologies, improving the reproductive outcome. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects the western diet habits. However, the effects of CoQ10 on reproduction under obesity conditions are still little known. The aim of this work was to evaluate the effect of Coq10 on the ovarian function in obesity. For that purpose, 22 day old female Wistar rats were divided in 2 groups that were fed ad libitum with standard rodent chow diet (Control groups) and CAF (Obese groups). After 7 weeks of diet protocol, half rats of each group received CoQ10 (5 mg/kg) orally for 13 days; while the others received vehicle. Animals (Ctrl, Ctrl+CoQ10, Obese and Obese+Coq10) were sacrificed on estrus phase; blood and ovaries were collected. Results: Estrous cycles were altered by obesity. Moreover, ovarian function was altered by obesity since: the number of corpora lutea was lower in obese rats compared to controls (p