Maternal obesity impairs uterine contractile activity prior to implantation

BAZZANO, MV; SARRIBLE, GB; BERÓN DE ASTRADA MARTÍN; ELIA EVELIN MARIEL

Jornada; XX Jornadas Anuales de la Sociedad Argentina de Biología (SAB)-XVII Jornadas de la Sociedad Uruguaya de Biociencias (SUB), Segundas Jornadas Rioplatenses de Biología; 2018

Obesity leads to several reproductive disorders. Using cafeteria diet (CAF)-induced obesity as animal model, we showed that the uterine β2 adrenergic receptor (β2AR) expression is increased and embryo distribution is altered by obesity prior to implantation. β2AR signaling has a critical role in embryo positioning by controlling myometrial relaxation. The aim of the present study was to determine whether obesity alters the uterine contractile activity and if it is due to the β2AR signaling disruption. Twenty two days old female wistar rats were divided into 2 groups that were fed ad libitum during 60 days with: standard rodent chow (Controls) and CAF (Obeses). Then, rats were mated, euthanized on 4.5gd (pre-implantation) and the uterine contractile activity was analyzed. Frequency of the spontaneous uterine contractions was similar between uteri from control and obese rats. However, the amplitude of theses contractions were higher in obese rats compared to controls (p