CONSECUENCES OF OBESITY ON THE FOLLICULOGENESIS

BAZZANO MARÍA VICTORIA; ELIA EVELIN MARIEL; MORALES ROSA MARÍA; GIACOLLO ALEJANDRA; PAZ DANTE AGUSTÍN; PUSTOVRH MARÍA CAROLINA

Congreso; Primer encuentro Rioplatense de Biología; 2012

Obesity is the most important non transmissible disease worldwide. It affects the reproductive health since obese women have high rates of menstrual dysfunction, anovulation, infertility, etc. The aim was to study whether obesity alters the follicular development. Female Wistar rats were fed ad libitum with three different diets: A) control group was fed with a standard diet. B) The DC group, received a high caloric diet with a pellet made with cookies, peanuts, butter, etc. C) The DCI group was offered with food directly that was periodically changed: chocolate chip cookies, peanuts, sausages, etc. In the DC and DCI groups, we detected an increase in the caloric intake and in the rates of weight gain, as well as in the glucose serum levels, respect to the control group. Cholesterol and triglyceride serum levels were normal in all groups. Respect to the ovaries, obesity did not alter the number of follicles in different stages of development, although we detected the presence of cystic follicles and follicles showing multiple oocytes in the DCI group. We conclude that the diet-induced obesity alters follicular development and those changes depends on the type of diet.