INVESTIGADORES
MARIN BURGIN Antonia
congresos y reuniones científicas
Título:
Modulation of piriform cortex neuronal activity by inputs from basolateral amygdala and lateral entorhinal cortex
Autor/es:
OLIVIA PEDRONCINI; NOEL FEDERMAN; ANTONIA MARIN BURGIN
Reunión:
Congreso; XXXIII Sociedad Argentina de Investigación en Neurociencias (SAN); 2018
Resumen:
Piriform cortex is the main region of the olfactory cortex where olfactory information is encoded. It receives sensory afferences from the olfactory bulb but also from other higher order brain regions such as the entorhinal cortex and the amygdala. Here we study how the basolateral amygdala (BLA) and the lateral entorhinal cortex (LEC) are functionally connected to the posterior piriform cortex (pPC). We infected the BLA and the LEC with adeno-associated virus expressing channelrhodopsin (ChR2-AAV) under CamKIIa or Parvalbumin promoters to activate either excitatory or inhibitory neurons respectively. We recorded postsynaptic currents and spiking in different principal neurons of the pPC in response toresulting of photostimulation. We found that both excitatory and inhibitory long range projections coming from the BLA synapse preferentially onto pyramidal neurons in of the deep layers of pPC and do not contact semilunar neurons. Moreover, we discover that inputs from both BLA and LEC can modulate the spiking activity of pPC neurons evoked by electric stimulation of the afferent pathway. Deciphering the interaction between sensory ?bottom-up? and ?top-down? projections from higher brain areas will shed light on the understanding of how the brain could adaptively shape sensory cortical activity according to behavioral needs.