INVESTIGADORES
URBANO SUAREZ Francisco Jose
congresos y reuniones científicas
Título:
Modafinil and Methamphetamine differentially activate c-Fos and FosB in the mouse striatum
Autor/es:
RAINERI M; GONZALEZ B; GOITIA B; CADET JL; URBANO FJ; BISAGNO V
Lugar:
HUERTA GRANDE, CORDOBA ARGENTINA
Reunión:
Congreso; XXVIII CONGRESO ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN EN NEUROCIENCIAS. REUNIÓN SATELITE/NEUROBIOLOGÍA DEL COMPORTAMIENTO: NEUROETOLOGÍA y NEUROBIOLOGÍA DE LA MEMORIA EN EL CONO SUR; 2013
Institución organizadora:
SOCIEDAD ARGENTINA DE INVESTIGACIÓN EN NEUROCIENCIAS.
Resumen:
Neurochemistry and Neuropharmacology. Poster Number 189 / Session 3------------------------------------------------------------------------------ Modafinil (MOD) is an antinarcoleptic drug used off-label to treat psychostimulant addiction. High doses of METH can induce neurtoxicity in different brain areas. In the present study we aimed to explore MOD and METH acute effects on c-Fos and Fos-B activation (immediate early genes used as an index of neuronal activation) in striatal tissue. Female C57/Bl-6 mice were treated with a METH binge protocol (4x5mg/kg, i.p., 2 h apart) co-administrated with MOD (2x90 mg/kg, i.p., 1 h bef. 1st & 3rd METH inj.). We also investigated the effects of both psychostimulants in locomotor activity, catecholamine striatal content (by HPLC). METH and MOD administration induced hyperlocomotion compared to salines (p
