INVESTIGADORES
URBANO SUAREZ Francisco Jose
artículos
Título:
Modafinil enhances thalamocortical activity by increasing neuronal electrotoic coupling
Autor/es:
URBANO FJ; LEZNIK E; LLINAS RR
Revista:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Editorial:
NATL ACAD SCIENCES
Referencias:
Lugar: Washington DC, USA; Año: 2007 vol. 104 p. 12554 - 12559
ISSN:
0027-8424
Resumen:
Modafinil (Provigil, Modiodal), an antinarcoleptic and moodenhancing drug, is shown here to sharpen thalamocortical activity and to increase electrical coupling between cortical interneurons and between nerve cells in the inferior olivary nucleus. Alter irreversible pharmacological block of connexin permeability (i.e., by using either 18-beta-glycyrrhetinic derivatives or mefloquine), modafinil restored electrotonic coupling within 30 min. It was further established that this restoration is implemented through a Ca2+/calmodulin protein kinase II-dependent step.
