MOLECULAR NEUROBIOLOGY OF MEMORY IN NEOHELICE

FELD M; MEDINA C; ROMANO A; FREUDENTHAL R

Neohelice granulata, a Model Species for Studies on Crustaceans

Cambridge Scholars Publishing

Año: 2020;

Memory consolidation, reconsolidation, and extinction require the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and regulation of gene expression. These molecular processes promote the stabilization of the memory trace in neurons of activated circuits. We studied such molecular mechanisms in the context-signal associative learning paradigm of the crab Neohelice granulata. Specifically, we explored the role of different molecular processes such as cAMP-dependent protein kinase (PKA), extracellular- signal-regulated kinase (ERK), nuclear factor kappa B (NF-κB) transcription factor, the ubiquitin-proteasome system of protein degradation, epigenetic mechanisms like histone acetylation, amyloid- beta, and its precursor protein, and NMDA receptors. This chapter reviews the most salient results obtained over two decades of research on molecular processes involved in this memory model.