INVESTIGADORES
FERNANDEZ LARROSA Pablo Nicolas
artículos
Título:
Oxytocin and prostaglandins F2α and E2 do not enhance HIV antigen production in vitro
Autor/es:
A. CEBALLOS; R.D. RABINOVICH; S. MARQUINA; P. N. FERNÁNDEZ LARROSA; L. A. MARTÍNEZ PERALTA
Revista:
ARCHIVES OF VIROLOGY
Editorial:
Springer Wien
Referencias:
Año: 2003 p. 531 - 535
ISSN:
0304-8608
Resumen:
Summary. Oxytocin and prostaglandins (PGs) are hormones involved in labor and are used clinically for its induction. In this study the effect of oxytocin, PGF2α, and PGE2 on Humour immunodeficiency virus-1 production in acutely and persistently infected cells was measured. No significant effect on p24 antigen production was found with oxytocin or PGs, except for a transient decrease in persistently infected cells treated with 1 µM PGF2α. These results showed that oxytocin and PGs could be used clinically for labor induction without any direct enhancement in viral production. Besides, the results with PGF2α at the highest concentration studied may indicate a pharmacological effect.
