INVESTIGADORES
FREUDENTHAL Ramiro A. M.
congresos y reuniones científicas
Título:
Protein acetylation and synaptic composition during Inhibitory Avoidance Long-Term memory consolidation in mouse hippocampus
Autor/es:
LAURA ESQUIVEL; ANGELES SALLES; JULIA BUSSO; MARIA DEL CARMEN KRAWCZYK; MARIANO BOCCIA; RAMIRO FREUDENTHAL
Lugar:
Belin
Reunión:
Congreso; 11th FENS Forum of Neuroscience; 2018
Institución organizadora:
FENS
Resumen:
Protein acetylation affects synaptic plasticity and memory, but its effects on synapse composition ?in vivo? during long term memory consolidation have not been addressed. Here we show that there is a correlation between the synaptic protein acetylation level and the synaptic protein composition at hippocampus during memory consolidation. We also show that altering the acetylation levels by administration of a Lysine deacetylase inhibitor specific for KDAC6 (mainly cytoplasmic) immediately after training facilitates retention at testing. These results suggest that the post translation modification, lysine acetylation, has a role regulating the synaptic changes that occur during memory consolidation.
