CHARACTERIZATION OF THE SYNAPTIC NF-KAPPAB POOL

FREUDENTHAL RAMIRO; HEPP YANIL; ROMANO ARTURO

Huerta Grande, Córdoba

Taller; I Reunión Conjunta en Neurociencias (IRCN); 2009

Taller Argentino de Neurociencias y san

  The transcription factor NF-kappaB is involved in the gene expression regulation that follows a neuronal plasticity event. In memory models, it activates in a biphasic fashion, translocating to the cellular nucleus immediately after a long term memory inducing training (LTMIT) and 6 hours after. The sub-cellular localization of this transcription factor shows not only a cytoplasmatic perinuclear localization but also a synaptic pool of NF-kappaB, that activates, also after a LTMIT . This work characterizes the NF-kappaB containing synapses as a way of investigating the molecular pathways involved in its activation and its function in the synapse during neuronal plasticity.