MOLECULAR NEUROBIOLOGY OF MEMORY IN NEOHELICE

MARIANA FELD; ACOSTA GB; ARTURO ROMANO; RAMIRO FREUDENTHAL

Neohelice granulata: a model species for the study of decapod crustaceans

CAMBRIDGE SCHOLARS PUBLISHING

Año: 2019; p. 71 - 101

Memory consolidation, reconsolidation and extinction require the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and gene expression regulation. These molecular processes promote stabilization of the memory trace in neurons of activated circuits. We studied such molecular mechanisms in the context-signal associative learning paradigm of the crab Neohelice granulata. Specifically, we explored the role of different molecular processes such as cAMP-dependent protein kinase (PKA), extracellular-signal regulated kinase (ERK), nuclear factor kappa B (NF-κB) transcription factor, the ubiquitin-proteasome system of protein degradation, epigenetic mechanisms like histone acetylation, amyloid beta and its precursor protein, and NMDA receptors. This chapter reviews the most salient results obtained over two decades of research on molecular processes involved in this memory model.