INVESTIGADORES
FREUDENTHAL Ramiro A. M.
artículos
Título:
Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus.
Autor/es:
FREUDENTHAL R, LOCATELLI F, HERMITTE G, MALDONADO H, LAFOURCADE C, DELORENZI A, ROMANO A.
Revista:
NEUROSCIENCE LETTERS
Referencias:
Año: 1998 vol. 20 p. 143 - 146
ISSN:
0304-3940
Resumen:
Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/ NFkappa-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/kappa-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/kappa-B like DNA-binding activity in the brain is specifically related to LTH formation.
