INVESTIGADORES
SREBROW Anabella
artículos
Título:
The fibronectin gene as a model for splicing and transcription studies.
Autor/es:
KORNBLIHTT AR; PESCE CG; ALONSO CR; CRAMER P; SREBROW A; WERBAJH SE; MURO AF
Revista:
FASEB JOURNAL
Editorial:
FEDERATION AMER SOC EXP BIOL
Referencias:
Año: 1996 vol. 10 p. 248 - 257
ISSN:
0892-6638
Resumen:
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The
fibronectin (FN) gene has become paradigmatic to illustrate genome evolution by
exon shuffling, generation of protein diversity by alternative mRNA splicing,
and topological coordination between transcription and splicing. Alternative
splicing in three sites of the primary transcript gives rise to multiple FN
polypeptides. This process is cell type-, development- and age-regulated. The
different FN variants seem to play specific roles in FN dimer secretion, blood
clotting, adhesion to lymphoid cells, skin wound healing, atherosclerosis, and
liver fibrosis. This review focuses on function assignment to the alternatively
spliced segments, as well as on the external signals and cis-acting sequences
that control the mechanisms of alternative splicing. We also discuss FN
transcriptional regulation in response to viral transformation, growth factors,
and cyclic AMP in the light of promoter architecture and its interaction with
specific transcription factors. The relevance of FN RNA tracks as assembly
lines of coordinated transcription and RNA processing is also addressed.