INVESTIGADORES
SREBROW Anabella
artículos
Título:
A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression.
Autor/es:
ROSKELLEY CD; SREBROW A; BISSELL M J
Revista:
CURRENT OPINION IN CELL BIOLOGY
Editorial:
CURRENT BIOLOGY LTD
Referencias:
Año: 1995 vol. 7 p. 736 - 747
ISSN:
0955-0674
Resumen:
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A
dynamic and reciprocal flow of information between cells and the extracellular
matrix contributes significantly to the regulation of form and function in
developing systems. Signals generated by the extracellular matrix do not act in
isolation. Instead, they are processed within the context of global signalling
hierarchies whose constituent inputs and outputs are constantly modulated by
all the factors present in the cell's surrounding microenvironment. This is
particularly evident in the mammary gland, where the construction and
subsequent destruction of such a hierarchy regulates changes in tissue-specific
gene expression, morphogenesis and apoptosis during each developmental cycle of
pregnancy, lactation and involution.
