Write and rewrite memories: the role of the reconsolidation function in memory updating.

ME PEDREIRA

Mar del Plata

Congreso; Reunion Anual de la Sociedad Argentina de Fisiologia; 2018

SAFIS

The ability to make predictions based on stored information is a general coding strategy. Would this capacity imply an important flexibility to rewrite memories as a consequence of a permanent changing world? In our field it is widely accepted that after acquisition, a short-term memory require a consolidation process, which turns this labile trace into a stable and long lasting one. Accepting the flexibility we can postulate that memories are dynamic rather than static and, after being consolidated, they can be modified through further experience. In the last years, it has been shown that acquired memories can become active and update its content or strength by the labilization-reconsolidation process. More specifically, inactive memories can be reactivated through the presentation of cues (reminders) already existent at the time of acquisition. This results in memory reactivation (labilization), followed by a process of re-stabilization (reconsolidation).Using a behavioural approach, I am going to show you our results, supporting the reconsolidation functions in a declarative memory in Humans. Then, our results in the searching of the neural footprints associated with the strengthening function with functional magnetic resonance imaging (fMRI). Finally, I want to analyze not only the future avenues whereas the reconsolidation process could open a novel therapeutic window to modify dysfunctional memories and/or to improve memories of everyday life, but also as a mechanism for maintenance of some psychopathologies such as anxiety disorders.