Identification of a Novel Retrieval-Dependent Memory Process in the Crab Neohelice granulata?

MERLO SANTIAGO; M JIMENA SANTOS; EMILIANO MERLO; M.E. PEDREIRA

Londres

Congreso; European Neuroscience Conference for Doctoral Students (ENCODS) 2021; 2021

Federation of European Neuroscience Societies

Paired presentations of a conditioned stimulus (CS) with an unconditioned stimulus (US) lead to the formation of an associative CS-US memory. In animals with a fully consolidated CS-US memory, presentation of the CS alone could trigger alternative memory processes. While a brief exposure to the CS can trigger reconsolidation of the original memory, a prolonged CS exposure will trigger memory extinction. The conditioned response is maintained after reconsolidation, but is inhibited after extinction, presumably by the formation of a new inhibitory memory trace. In rats and humans, it has been shown that CS exposure of intermediate duration leaves the memory in an insensitive or limbo state. Limbo is characterised by the absence of reconsolidation or extinction. Here we investigated the evolutionary conserved nature of limbo using a contextual Pavlovian conditioning (CPC) paradigm in the crab Neohelice granulata.