Memory reconsolidation in humans: deep understanding of the reactivation and re-stabilization process.

PICCO SOLEDAD; RODRIGO FERNANDEZ; M.E. PEDREIRA

Londres

Congreso; BeOnline 2021 Conference. (https://beonlineconference.com/beonline2021/; 2021

Gorilla org

Consolidated memories can be reactivated into a labile state by the presentation of a reminder. The reactivation of the memory trace is followed by a process of re-stabilization known as reconsolidation. Moreover, it has been demonstrated that the reconsolidation process could be the tool to update memories in strength and content. This unique role opens new venues for therapeutic applications targeting dysfunctional memories. The reconsolidation process, its functionality and its limiting conditions have been widely studied at a behavioural and pharmacological level, but little is known about whether this process could occur in an online experiment performance, and which measures would be relevant. Here we aim to design a protocol targeting memory reactivation and the following re-stabilization stage to assess and characterize the dynamics of the process of an aversive and a neutral memory in humans. We suggest that there are several boundary conditions for this process to occur. In particular, concerning the structure of the reminder, the salience or valence of the memory to recall, and the information present at the time of the reminder that allow to triggers or not the reactivation process.