SUBGINGIVALLY APPLIED MINOCYCLINE MICROGRANULES IN SUBJECTS WITH CHRONIC PERIODONTITIS. A RANDOMIZED CLINICAL AND MICROBIOLOGICAL TRIAL

VERÓNICA B CHIAPPE ; MARIEL V GÓMEZ ; CRISTINA RODRÍGUEZ ; MARILINA FRESOLONE ; ADALÍ PECCI ; HUGO J ROMANELLI

ACTA ODONTOLOGICA LATINOAMERICANA : AOL.

Asociación Odontológica Argentina

Año: 2015 vol. 28 p. 122 - 131

0326-4815

The aim of this study was to evaluate clinical and microbiological effects of subgingival minocycline microgranules when used as an adjunct to scaling and root planing in subjects with Chronic periodontitis. Twenty-six non-smoker volunteers participated in the study. Four opposite sites, clinically standardized, with bleeding on probing (BOP) and pocket depth (PD) ≥ 6 mm were selected. BaselineBOP, PD and Clinical attachment level (CAL) were measured and microbiological samples were collected from the study sites and analyzed using PCR. Porphyromonas gingivalis (Pg) Tannerella forsythia (Tf), Treponema denticola (Td) andAggregatibacter actinomycetemcomitans (Aa) were detected. One side of the mouth was randomly allocated to the experimental treatment: scaling and root planing plus minocycline microgranules (Test group=T) and the other side of the mouth toscaling and root planing alone (Control group=C). At days 30 and 90, clinical and microbiological examination was repeated. After 30 days BOP was reduced to 81% in C and to 12% the in T and at day 90 to 58% in C and to 8% in T (p