Expression of TGFBR1, TGFBR2, TGFBR3, ACVR1B and ACVR2B is altered in ovaries of cows with cystic ovarian disease

MATILLER, VALENTINA; HEIN, GUSTAVO J; STASSI, ANTONELA F; ANGELI, EMMANUEL; BELOTTI, E MATÍAS; ORTEGA, HUGO H; REY, FLORENCIA; SALVETTI, NATALIA R

REPRODUCTION IN DOMESTIC ANIMALS (1990)

WILEY-BLACKWELL PUBLISHING, INC

Año: 2019 vol. 54 p. 46 - 54

0936-6768

The objective of the present study was to examinethe expression of transforming growth factor beta receptor (TGFBR)1, TGFBR2,TGFBR3, Activin Receptor (ACVR)1B and ACVR2B in ovaries of cows with CysticOvarian Disease (COD). The expression of the selected receptors was determinedby immunohistochemistry in sections of ovaries from cows with ACTH-induced and spontaneousCOD. Expression of TGFBR1 and TGFBR3 was higher in granulosa cells of cysts fromcows with spontaneous COD than in tertiary follicles from the control group. Additionally,TGFBR3 expression was higher in granulosa cells of cysts from cows with ACTH-inducedCOD than in those from the control group and lower in theca cells ofspontaneous and ACTH-induced cysts than in tertiary control follicles. ACVR1Bexpression was higher in granulosa cells of tertiary follicles of cows with spontaneousCOD than in the control group, whereas ACVR2B expression was higher in cysts ofthe spontaneous COD group than in tertiary follicles from the control group. Thealterations here detected, together with the altered expression of the ligandspreviously reported, indicate alterations in the response of the ligands in thetarget cells, modifying their actions at cellular level. These data maycontribute to unravel the intraovarian signaling pathways and thus to theknowledge of the pathogenesis of COD.