Characterization of an incipient granulosa cell tumour in a Holstein cow: Steroid hormone receptors and coregulators expression

BELOTTI, EDUARDO M. EQUAL CONTRIBUTION; SACCO, SOFÍA C. EQUAL CONTRIBUTION; STASSI, ANTONELA F.; NOTARO, ULISES S.; ANGELI, EMMANUEL; ETCHEVERS, LUCAS; CHIARAVIGLIO, JUAN A.; ORTEGA, HUGO H.; SALVETTI, NATALIA R.

ANATOMIA HISTOLOGIA EMBRYOLOGIA-JOURNAL OF VETERINARY MEDICINE SERIES C

JOURNAL OF VETERINARY MEDICINE SERIES C

Lugar: Munich; Año: 2022 vol. 51 p. 62 - 68

0340-2096

The objective of this study was to describe a case of a granulosa cell tumour (GCT)of incipient formation and to characterize it by its immunohistochemical pattern andhormonal profile. The case presented corresponds to a 7-year-oldHolstein cow withoutreproductive disorders. No alterations were observed at rectal palpation, neitherin the ultrasonography nor in the hormonal profile. A GCT concomitant with normalfollicular development was diagnosed. Through a panel of immunohistochemicalmarkers, a highly differentiated pattern could be determined in the GCT, which preservesthe expression of steroid receptors (ESR1, ESR2 and PR) typical of granulosacells, but does not express the enzymes for the synthesis of androgens (CYP17A1)and oestrogens (CYP19A1). In addition, the expression of co-regulatorsof steroidhormone receptors and neuroendocrine markers was described for the first time in aGCT in cattle. These results increase the information about GCTs in cattle before theovarian function is compromised.