Abrogation of spontaneous liver tolerance during immune response to Candida albicans:

RENNA MS; FIGUEREDO CM; RODRIGUEZ GALAN M.C; ICELY P; PERALTA RAMOS JM; CORREA SG; SOTOMAYOR CE

INTERNATIONAL IMMUNOLOGY

OXFORD UNIV PRESS

Año: 2012 p. 1 - 11

0953-8178

Hepatic mononuclear cells (HMC) are a heterogeneous population with innate immune properties involved in the response to several pathogens. Herein, during the primary infection with Candida albicans, we observed dynamic changes in CD31, NK1 and NKT1 intrahepatic lymphoid subsets and albicans, we observed dynamic changes in CD31, NK1 and NKT1 intrahepatic lymphoid subsets and albicans, we observed dynamic changes in CD31, NK1 and NKT1 intrahepatic lymphoid subsets and albicans, we observed dynamic changes in CD31, NK1 and NKT1 intrahepatic lymphoid subsets and albicans, we observed dynamic changes in CD31, NK1 and NKT1 intrahepatic lymphoid subsets and Candida albicans, we observed dynamic changes in CD31, NK1 and NKT1 intrahepatic lymphoid subsets and, we observed dynamic changes in CD31, NK1 and NKT1 intrahepatic lymphoid subsets and  a significant increase in the absolute number of antigen-presenting cells (APC). The liver tolerogenic microenvironment sustained by higher levels of IL-10, transforming growth factor-b and IL-4 was severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable microenvironment sustained by higher levels of IL-10, transforming growth factor-b and IL-4 was severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable microenvironment sustained by higher levels of IL-10, transforming growth factor-b and IL-4 was severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable microenvironment sustained by higher levels of IL-10, transforming growth factor-b and IL-4 was severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable microenvironment sustained by higher levels of IL-10, transforming growth factor-b and IL-4 was severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable severely modified upon the robust IFN-g production after the fungal colonization. NKT cells purified from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingly, C. albicans per se was unable from infected animals released significant amounts of IFN-gamma and the production of this cytokine was exacerbated after a second contact with the fungus. Interestingl