Role of glucocorticoids in the bovine cystic disease: Expression of glucocorticoid receptor in the bovine ovary.

AMWEG NA; RODRIGUEZ FM; HUBER E; MARELLI BE; SALVETTI NR; REY F; ORTEGA HH

CELLS TISSUES ORGANS

KARGER

Lugar: Basel; Año: 2015

1422-6405

The aim of this study was to characterize theexpression of glucocorticoid receptor (GR) in the components of normal bovineovary and in animals with Cystic Ovarian Disease (COD). Changes in the protein andmRNA expression levels were determined in control cows and cows with COD by immunohistochemistry and real-time PCR. GR proteinexpression in granulosa cells was higher in cysts from animals with spontaneousCOD and ACTH-induced COD than in tertiary follicles from control animals. Intheca interna cells, GR expression was higher in cysts from animals withspontaneous COD than in tertiary follicles from control animals. The increasein GR expression observed in cystic follicles suggests a mechanism of actionfor cortisol and its receptor through the activation / inactivation of specifictranscription factors. These factors could be related to the pathogenesis ofCOD in cattle.