Adesmia boronioides and Solidago chilensis, two novels herbal infusions with toxic effects against colon cancer derived cells.

GASTALDI, B.; ASSEF Y.A.; GONZÁLEZ, S. B.; MARINO GI.

Mar del Plata

Congreso; LXII Reunión Anual de SAIC; 2018

Sociedad Argentina de Investigación Clínica

The development and progression of colon cancer is strongly influenced by diet substances that enter in the digestive tract. Herbal infusions from medicinal plants usually contain phytochemicals that can restrain the development and progression of colon cancer in various ways. Flavonoids, an important group of these phytochemicals, report a recognized anti-inflammatory, antioxidant and signal-regulating properties. Adesmia boronioides and Solidago chilensis are two native medicinal plants that contain flavonoids and have reported promising antiproliferative activity against T-84 cells. Our aim was to study the toxic effects of herbal infusions obtained from A. boronioides and S. chilensis on Caco-2 and HT-29 cells as models of colon cancer. We observed by MTT assay (after 72 h) that the percentage of viable cells decreased with the increase in the concentration of freeze-dried infusions of both plant species (0 to 50 mg/ml) (p