Hidrogenación Quiral De Piruvato De Etilo Sobre Catalizadores Basados En Resinas De Intercambio Iónico

N. CARRARA; J. BADANO; G. MENDOW; D. RUIZ; C. VERA; M. QUIROGA

Córdoba

Congreso; XX Congreso Argentino de Catálisis; 2017

The use of noble metal catalysts supported on an ionic exchange resins was studied for the enantioselective hydrogenation of ethyl pyruvate to ethyl lactate. Good activity and moderate enantioselectivity values were obtained. Pt was the best active metal phase with higher enantioselectivity, followed by Pd, Au and Rh.A novel method for sintering of the metal particles was used and a controlled migration of the metal particles to the surface layers was observed. The reaction was found to be structure sensitive and the importance of the metal particle size for the adsorption of the chiral modifier was proved. There existed an optimal particle size that maximized the enantiomeric excess, corresponding to 24 h sintering.Two different chirality induction methods were tried: i) the addition of the modifier to the reaction media, ii) the modification of the catalyst in a swelling media prior to the reaction. The traditional method (i) showed good values of activities and moderate selectivities; while the swelling method proposed, showed better enantioselectivity.