Mecanismos Moleculares y Terapeuticos para Reducir la Inflamacion del Tejido Adiposo en la Obesidad

RAMIREZ D.C,; SANDRA E GOMEZ-MEJIBA

REVISTA PERUANA DE DIVULGACION CIENTIFICA EN GENETICA Y BIOLOGIA MOLECULAR

revista.igbmperu@outlook.com.pe Instituto de Genética Barbara McClintock (IGBM) Área de Divulgación Científica Lima, Perú

Año: 2016 vol. 1 p. 10 - 13

Adipose tissue (AT) inflammation in obesity is a key process linking obesity, systemic inflammation and metabolic syndrome. The understanding of the molecular mechanisms of adipogenesis/adiposity as well as inflammatory activation of macrophages is critical in the search of novel therapeutics to reduce AT inflammation in obesity. Herein, based on our clinical as well as biochemical data we discuss the role of two transcription factors involved in adipogenesis (Nrf-2) and inflammatory activation of macrophages (NFκB). We focus our discussion on strategies aimed at screening libraries of natural and synthetic compounds in the search for novel structures able to induce Nrf2 activation in adipocytes and to reduce NFκB activation in macrophages by using molecular and cellular models. The growing incidence of metabolic syndrome in obesity justifies the search for novel chemical structures to enhance adipogenesis and to reduce AT inflammation.