Effect of Adding a Galacto-Oligosaccharides/Fructo-Oligosaccharides (GOS/FOS®) Mixture to a Normal and Low Calcium Diet, on Calcium Absorption and Bone Health in Ovariectomy-Induced Osteopenic Rats

SEIJO, MARIANA; BRYK, GABRIEL; ZENI CORONEL, MAGALÍ; BONANNO, MARINA; RÍO, MARÍA ESTHER; PITA MARTÍN DE PORTELA, MARÍA LUZ; ZENI, SUSANA NOEMÍ

CALCIFIED TISSUE INTERNATIONAL

SPRINGER

Año: 2018 vol. 104 p. 301 - 312

0171-967X

Menopause is associated with bone loss. Prebiotics increase Ca, inorganic phosphorus (Pi), and Mg absorption, improvingbone health. These increases would supply an extra amount of minerals, decreasing bone resorption and possibly reversingovariectomy-induced bone loss. The present experimental study sought to evaluate the effect of adding a prebiotic GOS/FOS® mixture to a normal or a low Ca diet on Ca, Pi, and Mg absorption, in osteopenic rats. Four groups of n=8 rats eachwere OVX, and 8 rats were SHAM operated. All rats were fed a commercial diet for 45 days. They were then fed one of thefollowing diet for 45 days: C-0.5%: SHAM fed AIN 93 M containing 0.5%Ca; O-0.5% and O-0.3%: OVX rats fed AIN 93 M,containing 0.5% or 0.3%Ca, respectively; GF-0.5% and GF-0.3%: OVX rats fed AIN 93 M, containing 0.5% or 0.3%Ca+2.5%GOS/FOS®, respectively. At the end of the experimental time point, Ca, P, and MgAbs% was significantly higher in GF-0.5%and GF-0.3% as compared to the remaining groups (p