ISLA Maria Ines
Potential use of medicinal plants from Argentinean highland as agent anti-photoaging
EUGENIA ORQUEDA, MARIA; MORENO ALEJANDRA; ZAMPINI CATIANA; KARENT BRAVO; EDISON OSORIO; MARIA INES ISLA
Journal of cosmetic dermatology
Año: 2020 p. 1 - 9
Background: The overexposure to sun ultraviolet (UV) radiation produce photoagingby effect of free radicals on lipid, protein, and nucleic acid or by direct activation ofresponsible enzymes of cleavage of extracellular matrix components (EMC).Aims: To develop new anti-photoaging agents, the anti-aging activity of four ?jarillas?standardized extracts from Argentina (Zuccagnia punctata Cav., Larrea divaricata Cav.,Larrea cuneifolia Cav., and Larrea nitida Cav.) were examined.Methods: The effect on the activity and expression of enzymes related to photoaging(collagenase, hyaluronidase, elastase, tyrosinase) and the antioxidant capacity offour ?jarillas? extracts were examined.Results: The results suggest that ?jarillas? extracts could protect EMC by inhibitionof skin aging-related enzymes and suppression of the expression of metalloproteinases(MMP-1) in human skin fibroblasts from photoinduced damage. Modulation ofMMP-1 expression induced by UV radiation in human skin cells could be associated,at least in part, with the ROS scavenging capacity of ?jarilla? extracts. The extract ofZ punctata was more active than Larrea species extracts in all the trials. The activityof Z punctata and Larrea extracts could be ascribed to chalcones and lignans, majorconstituents of ?jarillas,? respectively.Conclusions: The results obtained would indicate the potential of these adapted speciesto live in arid zones of Argentina, exposed to high ultraviolet radiation in productionof cosmetic products and justify the promotion of their sustainable use and thedevelopment of crops.