In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of Ziziphus mistol from Argentina

ORUEDA EUGENIA; TORRES SEBASTIAN; ZAMPINI CATIANA,; ISLA MARÍA I,

Foods

MDPI

Año: 2022 vol. 11 p. 2125 - 2138

2304-8158

The Ziziphus mistol fruit (vulgar name mistol) is used in northwestern Argentinain traditional food and beverage preparations and popular medicines for liver and respiratorydisorders. Aims: The aim of this research was to evaluate the hypoglycemic and anti-inflammatoryactivity in pulp powders and sub-products (skin and seeds) of mistol fruit, along with their toxicity.Methods: Powders from mistol seeds, pulp, and skin were obtained. Antioxidant capacity andinhibitory activity against key enzymes involved in metabolic syndrome were determined by in vitroassays. Results: The mistol powders obtained from the different fruit parts reduced glucose bioaccessibility.Before and after simulated gastroduodenal digestion, the polyphenol-enriched extracts(PEE) obtained from mistol powders increased glucose uptake by yeast cells and inhibited the pivotalenzymes of the inflammatory pathway (cyclooxygenase-2, lipooxygenase-1, and phospholipase A2).The analyzed mistol powders did not show acute toxicity or genotoxicity in model organisms andcell cultures. Conclusions: These results evince the potentiality of both the pulp from Z. mistol fruitsand residual biomass (seeds and skin) to obtain biofunctional powders to use as supplements formetabolic disorders associated with chronic diseases