Controlling the Release in Mesoporous Silica Nanoparticles with Bioinspired Catechol-based Coatings

VILLAECIJA, MIGUEL ANGEL MORENO; NADOR, FABIANA; GUISASOLA, EDUARDO; BAEZA, ALEJANDRO; VALLET-REGÍ, MARÍA; RUIZ-MOLINA, DANIEL

Vilna

Workshop; HINT Workshop: Nanostructured materials: coatings, surfaces, bioceramics/-composites, membranes; 2016

Mesoporous silica nanoparticles (MSNs) have been playing an important role in the field of nanomedicine for the last years. Their high payloads and biocompatibility confer them outstanding properties to be considered for the design of drug delivery systems [1]. However, the control in the release of the cargo still remains a challenge since the naked MSNs present premature release in physiological medium. Inspired by this and taking into account the wide experience of our research group in the modification of several structures by one-step polymerization strategy based on catechol moieties in presence of ammonia solutions, [2,3] in this work we report the successful synthesis of uniform coatings of MSNs upon ammonia triggered polymerization of different monomeric and dimeric catechol units.The main results showed: I) the coating thickness around MSNs particles can be modified and used with differently functionalized catechol units, II) the premature cargo release of preloaded naked MSNs with drugs (as doxorubicin) was minimized upon particle coating after exposure to physiological media and different pHs conditions and III) some specific coatings have been shown to self-remove the MSN core (sacrificial template) without need of any harsh chemical reagent leading to the formation of stable pure polymeric capsules.These findings represent a very simple way to get efficient and smart responsive coatings around MSNs increasing the scope of these nanoparticulated systems for drug release.