Multifunctional Coordination Polymeric Nanoparticles. An alternative to classical nanoplatforms

F. NOVIO; F, NADOR; K. WNUK; J. LORENZO; L. AMORÍN; D. RUIZ-MOLINA

Barcelona

Workshop; 2nd Workshop on Nanomedicine UABCEI; 2013

Institut de Biotecnologia y de Biomedicina (UAB), in collaboration with the Campus of International Excellence (UAB-CEI)

Coordination polymers are a fascinating family of materials created from supramolecularassembly of metal ions and organic ligands that act as building blocks to generate asuperstructure with genuine and highly tailorable properties [1]. These systems present thecombined advantages of the classical metal nanoparticles and the polymeric nanoparticlesbased on pure organic materials for the application in medical therapy (drug delivery) anddiagnosis (bioimaging) [2].Our research group has focused in the synthesis of nanoscale coordination polymericparticles (CPPs). These nano-objects are able to encapsulate a wide variety of sustaces(drugs, metal nanoparticles, quantum dots, etc?) [3], and act as smart response materials[4]. The recent results include the optimization of encapsulation properties of these materialsand the surface functionalization to achieve new elegant biocompatible multifunctionalplatforms with interesting applications in medicine for drug delivery, bioimaging and targetingdirectionality for specific recognition. Moreover, the rational design of the new nanoplatformshas afforded new materials that exhibit smart responses against different external stimulisuch as temperature, pH, redox environments. Complementary studies of stability anddegradation processes have afford interesting results concerning the suitability of thesenanoparticles to be used in drug delivery control release. The precise design of thenanoparticles (size, shape and composition) allow to control the drug release profile andadequate them to a specific therapy actuation [5].The preliminary results indicate that these new multifunctional platforms open a new widevariety of possibilities to be used in therapy and diagnosis due to their high stability, lowtoxicity and high cellular uptake.