Customizable PLGA-encapsulated perfluorocarbon particles for in vivo 19F MRI

M. SRINIVAS; F. BONETTO; L. J. CRUZ; A. HEERSCHAP; C. G. FIGDOR; J. DE VRIES

Estocolmo

Conferencia; 18th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine; 2010

In our studies, we focused on cell labeling for MRI. However, the particles can be adapted for the experimental system, depending on the PFC encapsulated and the particle formulation. The addition of a fluorescent dye to the particles may also allow in vivo optical imaging, and flow cytometric and histological analyses of labeled cells after transfer to the subject. Another major advantage is that the PLGA particles present a stable surface for the covalent addition of targeting agents, such as  antibodies. We suggest that PLGA encapsulation is a suitable method for stabilizing perfluorocarbons in aqueous environments for a myriad of in vivo imaging and targeting applications.