Tetrachlorocarbonyliridates: water soluble carbon monoxide releasing molecules rate-modulated by the sixth ligand

BIKIEL, D.E.; GONZALEZ SOLVEYRA, E.; DI SALVO, F.; MILAGRE, H.M.S.; EBERLIN, M.N.; CORREA, R.S.; ELLENA, J.; ESTRIN, D.A.; DOCTOROVICH, F.

INORGANIC CHEMISTRY

AMER CHEMICAL SOC

Año: 2011 vol. 50 p. 2334 - 2345

0020-1669

ABSTRACT: A new family of compounds is presented as potentialcarbon monoxide releasing molecules (CORMs). These compounds,based on tetrachlorocarbonyliridate(III) derivatives, were synthe-sized and fully characterized by X-ray diffraction, electrospray massspectrometry, IR, NMR, and density functional theory calculations.The rate of CO release was studied via the myoglobin assay. The resultsshowed that the rate depends on the nature of the sixth ligand, trans toCO, and that a significant modulation on the release rate can beproduced by changing the ligand. The reported compounds are solublein aqueous media, and the rates of CO release are comparable with thosefor known CORMs, releasing CO at a rate of 0.03-0.58 μM min-1 in a10 μM solution of myoglobin and 10 μM of the complexes.