Delay of lung adenocarcinoma (LAC-1) development in mice by dietary oleic acid

PIEGARI M; SORIA EA; EYNARD AR; VALENTICH MA

NUTRITION AND CANCER

LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS

Lugar: Londres; Año: 2017 vol. 69 p. 1069 - 1074

0163-5581

Lung cancer is the leading cause of death by cancer, which is a major sanitary concern worldwide. Some nutrients, such as ω-9 fatty acids, have been proposed as anticancer agents. Thus, an olein enriched diet was assayed in a murine model of lung adenocarcinoma (LAC-1) to evaluate neoplastic and paraneoplastic evolution in BALB/c mice. The organic assimilation of dietary fatty acids wasconfirmed in liver by gas chromatography. This experimental oleic acid-containing diet increased animal survival and tumour latency (analysed by the Kaplan Meier method), improving neoplastic evolution and general status, with weak effects on the paraneoplastic syndrome (thymus atrophy, splenomegaly, splenocyte response to mitogen, blood anaemia and leucocytosis). Tumour lipidoxidation was not involved. Thus, diet enrichment with olein, a natural source of the ω-9 oleic acid, significantly delayed progression of LAC-1 and increased tumour latency and mice survival. These results support its use in nutritional management of cancer, with further studies being encouraged.