Pharmacoepidemiological approach of the predisposing factors for HAART failure in a HIV-positive cohort from Cordoba City (Argentina, 1995-2005)

SORIA EA; CADILE II; ALLENDE LR; KREMER LE

INTERNATIONAL JOURNAL OF STD & AIDS.

ROYAL SOC MEDICINE PRESS LTD

Año: 2008 vol. 19 p. 335 - 338

0956-4624

Highly active antiretroviral therapy (HAART) restores immunity, avoids resistance and delays disease progression. Nonetheless, adverse medicament reactions (AMRs) and therapeutic failure (TF) are still deleterious events. Consequently, their predisposing factors should be evaluated. Data from 181 men and 28 women of an Argentinean cohort (1995–2005) were collected and analysed by logistic regression, studying 63 schemes (15 active principles). The AMRs were the main cause of scheme change, followed by TF and medicament simplification, without influence of age and sex. Twenty-nine schemes exhibited TF at least once. Compared with zidovudine–lamivudine–nevirapine (success: >75%), the following schemes fail more frequently (P=3 protease inhibitors (11-fold). Inadequate patient adherence preceded failure (>95%), but not successful treatments, with a strong AMR–TF association (P