Tetrachlorocarbonyliridates: Water-Soluble Carbon Monoxide Releasing Molecules Rate-Modulated by the Sixth Ligand

BIKIEL, D.; GONZALEZ SOLVEYRA, E.; DI SALVO, F.; MILAGRE, H.; M. NOGUEIRA EBERLIN; CORREA, R.; ELLENA, J.; ESTRIN, D; DOCTOROVICH, F.

INORGANIC CHEMISTRY

AMER CHEMICAL SOC

Año: 2011 vol. 50 p. 2334 - 2345

0020-1669

A new family of compounds is presented as potential carbon monoxide releasing molecules (CORMs). These compounds, based on tetrachlorocarbonyliridate(III) derivatives, were synthesized and fully characterized by X-ray diffraction, electrospray mass spectrometry, IR, NMR, and density functional theory calculations. The rate of CO release was studied via the myoglobin assay. The results showed that the rate depends on the nature of the sixth ligand, trans to CO, and that a significant modulation on the release rate can be produced by changing the ligand. The reported compounds are soluble in aqueousmedia, and the rates ofCOrelease are comparable with those for known CORMs, releasing CO at a rate of 0.03-0.58 μMmin-1 in a10 μM solution of myoglobin and 10 μM of the complexes.