A unique family of stable and water-soluble S-nitrosothiol complexes

PERISSINOTTI, L.; LEITUS, G.; SHIMON, L.; ESTRIN, D.; DOCTOROVICH, F.

INORGANIC CHEMISTRY

AMER CHEMICAL SOC

Año: 2008 vol. 47 p. 4723 - 4733

0020-1669

ABSTRACT In this work we present a complete and detailed experimental characterization and theoretical study of a variety of coordinated S-nitrosothiols, such as cysteine derivatives, mercaptosuccinic acid, benzyl thiol and phenyl thiol. Some of them are extremely unstable and sensitive in free form. Strikingly, in contrast with free S-nitrosothiols, we found that upon coordination to iridium, they become very stable even in aqueous solutions. The study of this coordinated complexes provide further insight on the elucidation of structural aspects dealing with the nature of the S-N bond in RSNOs, a fact which still remains a matter of controversy. KEYWORDS iridium, nitrosyl, S-nitrosothiol, coordination chemistry, life-time, stability.S-nitrosothiols, such as cysteine derivatives, mercaptosuccinic acid, benzyl thiol and phenyl thiol. Some of them are extremely unstable and sensitive in free form. Strikingly, in contrast with free S-nitrosothiols, we found that upon coordination to iridium, they become very stable even in aqueous solutions. The study of this coordinated complexes provide further insight on the elucidation of structural aspects dealing with the nature of the S-N bond in RSNOs, a fact which still remains a matter of controversy. KEYWORDS iridium, nitrosyl, S-nitrosothiol, coordination chemistry, life-time, stability.S-nitrosothiol, coordination chemistry, life-time, stability.