INVESTIGADORES
DISALVO Edgardo anibal
artículos
Título:
Effect of dolichyl monophosphate on the permeability properties of lipid membranes
Autor/es:
S. ALONSO ROMANOWSKI; M. FELIZ; E. BELOCOPITOU ; E.A. DISALVO
Revista:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 1998 vol. 946 p. 389 - 396
ISSN:
0005-2736
Resumen:
The effect of dolichyl monophosphate on the permeability properties of dimyristoylphosphatidylcholine bilayers to alkaline cations, Ca2+ and glucose has been determined by stop-flow spectrophotometry. The results show that, in con trast to free dolichol effects, the monophosphate derivative increased the permeability following a decreasing order of the permeating particle size. Phase diagrams indicate that dolichyl monophosphate is fully incorporated into the phosphatidylcholine bilayer around 0.75% weight/weight ratio. For these ratios, the permeation of ions is higher in the gel than in the liquid crystalline state.
