Yacon diet supplementation decreased collagen deposition in non alcoholic fatty liver

ALEMAN MN; SANCHEZ SS; HONORE SM

Mar del Plata, Buenos Aires

Congreso; LI Reunión Anual de la Sociedad Argentina de Investigaciones en Bioquímica y Biología Molecular; 2015

Sociedad Argentina de Investigaciones en Bioquímica y Biología Molecular

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Excessive dietary carbohydrate consumption, especially excessive fructose consumption are linked to metabolic syndrome, being associated with hypertriglyceridemia, hypertension, insulin resistance and diabetes. Fructose is metabolized principally in the liver, where it is converted into fatty acids, which are stored in the form of triglycerides leading to NAFLD. We analyzed the hepatic effects of S. sonchifolius (yacón) roots in fructose-enriched diet. Adult male Wistar rats were maintained on a rat standard chow and then animals were randomly separated into a control group (SD: water a.l.) and a fructose supplemented group (FED: fructose 10% w/v, a.l.). After 12 w FED rats, were randomly assigned according to the treatment: FED or a FED+Y (340mg yacon flour/kg bw). Administration yacon flour for 16 w lowered visceral fat pad and hepatic weights compared to FED rats. Yacon supplementation was associated with a decrease in serum and hepatic triglycerides, cholesterol, VLDL, ALT and AST activities. Moreover, FED+Y rats showed improved hepatic steatosis, inflammation and limited hepatic fibrillar collagen deposition. Levels of TGF-b and p-Smad2/3 were decreased in FED+Y livers. In summary, yacon roots diet supplementation would seem beneficial for prevention of NAFLD and its metabolic consequences.