Smallanthus sonchifolius (yacon) flour ameliorates high-fat diet-induced non-alcoholic fatty liver disease (en prensa)

DIAZ MIRANDA E.N.; GRANDE M.V.; SANCHEZ S.S.; HONORE S.M.

Tafi del Valle, Tucumán

Jornada; XXXIX Annual Scientific Meeting of the Tucuman Biology Association; 2022

Asociacion de Biologia de Tucumán

Nonalcoholic fatty liver disease (NAFLD), a component of the cardiometabolic syndrome, has emerged as one of the most common etiologies of chronic liver disease. NAFLD, is strongly associated with obesity and is characterized by an irregular deposition of triglycerides in hepatocytes and increased oxidative stress. Current management is rooted in attenuating the risk factors such as gradual weight loss through lifestyle modifications with a focus on nutrition and exercise. The roots of Smallanthus sonchifollus (yacon) have shown benefits for glucose control and body weight in obese rats. The present study was designed to investigate the efficacy of yacon flour in the treatment of high-fat diet (HFD)-induced NAFLD in rats. Male Wistar rats were fed a standard diet (CD) or HFD for 12 weeks and then were divided into the following groups: CD, HFD, and HFD plus yacon (680mg/kg/bw, HFDY), for 8 continuous weeks. NAFLD was examined in terms of body weight, lipid profiles, liver function markers, and histology. Our results showed that yacon flour supplementation significantly reduced HFD-induced body weight, hyperlipidemia, and intrahepatic lipid accumulation (p