One-pot synthesis of xanthones using a novel copper-based magnetically recoverable nanocatalyst

CINTIA A. MENÉNDEZ; FABIANA NADOR; GABRIEL RADIVOY; DARÍO C. GERBINO

Conferencia; 17th Int. Electron. Conf. Synth. Org. Chem; 2013

A versatile and straightforward strategy to construct a xanthone skeleton via an intermolecular catalytic coupling of 2-substituted benzaldehydes and a wide range of phenols has been developed. For this purpose, a novel and magnetically recoverable catalyst consisting of copper nanoparticles on nanosized silica coated maghemite in absence of ligand is presented. The reaction proceeds smoothly without the need to preactivate the aldehyde carbonyl group. It can tolerate various functional groups and provides an efficient protocol for the generation of a small library of xanthones in high yield.