A three-domain copper-nitrite reductase with a unique sensing loop

OPPERMAN, DIEDERIK J.; MURGIDA, DANIEL H.; DALOSTO, S.D; BRONDINO, CARLOS D.; FERRONI, FELIX M.

International Union of Crystallography

IUCrJ

Año: 2019 vol. 6 p. 248 - 258

2052-2525

TsNirKis the first three-copper three-domain nitrite reductase harbouringGln-coordinated type 1 copper centres. All the structuralproperties of TsNirK point to an enzyme that, despite having severalof the essential catalytic features present in other NirKs, shows twodistinctive and unique characteristics: firstly, the putative T1CuC>> T1CuN >> T2Cu electron-transfer pathway along the samesubunit; and secondly, more importantly, is the presence of theSerCAT residue at theenzyme substrate sensing loop, which opens a new paradigm in thiswidely studied family of enzymes.p { margin-bottom: 0.08in; direction: ltr; color: rgb(0, 0, 10); line-height: 115%; }p.western { font-family: "Calibri", serif; font-size: 11pt; }p.cjk { font-family: "Calibri"; font-size: 11pt; }p.ctl { font-family: "Calibri"; font-size: 11pt; }a:link { }