Effect of xanthones on lipid membranes

CEJAS, J.P.; ALARCÓN,L.; GERBINO, D.; DISALVO, E ANIBAL; FRIAS, M. DE LOS ANGELES

Buenos Aires

Congreso; XLVI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE BIOFÍSICA (SAB).; 2017

Xanthones are heterocyclic compounds with the dibenzo-γ-pyrone structure. In nature xanthones are a class of secondary metabolites that produced commonly in several plant families. The fused rings that form the xanthonic system and the eight possible types of substitution provide an interesting framework from which different systems can be designed. Interest in their chemical and structural properties has increased due to many biological activities such as inhibitory activity in tumor cell lines. The interest in this compound is related to its possible integration to biological membrane in order to design lipid particles for drug delivery. Thus, it is of interest to study the effect it may have on membrane structure. For this reason we investigated the insertion of Xanthone (9H-xanthen-9-one) and Hydroxy-xanthone (1-hydroxy-9H-xanthen-9-one) in lipid monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), di-Oleoylphosphatidylcholine (DOPC), 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine (etherPC), Phosphatidylethanolamine (16:0 DPPE) by measuring the changes in the dipole potential, the area per lipid and compressibility properties. In addition, the changes in packing and membrane polarity was studied by measuring Generalized Polarization in gel and liquid crystalline states.