ANTIRADICAL ACTIVITY OF GALLIC ACID INCLUDED IN LIPID INTERPHASES

SALCEDO, C.L.; FRÍAS, M.A.; CUTRÓ, A.C.; NAZARENO, M.A.; DISALVO, E.A.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 p. 2656 - 2661

0005-2736

Polyphenols are well known as antioxidant agents and by its effects on the hydration layers of lipid interphases. Among them, gallic acid and its family are able to decrease the dipole potential and to act in water as a strong antioxidant. In this work we have studied both effects on lipid interphases in monolayers and bilayers of dimyristoylphosphatidylcholine. The results show that Gallic acid increases the negative surface charges of large unilamellar vesicles (LUVs) and decreases the dipole potential of the lipid interphase. As a result, positively charged radical molecules such as ABTS?+ are able to penetrate the membrane forming an association with GA. These results allow discussing the ARA of GA at the membrane phase which may be taking place in water spaces between the lipids.