Antiradical activity of gallic acid included in lipid interphases

CECILIA L. SALCEDO; MARÍA DE LOS ANGELES FRÍAS; ANDREA C. CUTRÓ; MONICA NAZARENO; ANIBAL E. DISALVO

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 vol. 1838 p. 2656 - 2661

0005-2736

Polyphenols arewell known as antioxidant agents and by their effects on the hydration layers of lipid interphases. Among them, gallic acid and its derivatives are able to decrease the dipole potential and to act inwater as a strong antioxidant. In this work we have studied both effects on lipid interphases in monolayers and bilayers of dimyristoylphosphatidylcholine. The results show that gallic acid (GA) increases the negative surface charges of large unilamellar vesicles (LUVs) and decreases the dipole potential of the lipid interphase. As a result, positively charged radical species such as ABTS?+are able to penetrate themembrane forming an associationwith GA. These results allowdiscussing the antiradical activity (ARA) of GA at themembrane phasewhichmay be taking place in water spaces between the lipids