INVESTIGADORES
CIOLINO Andres Eduardo
artículos
Título:
Improvement in poly(E-caprolactone) bio-activity. Structural characterization and in vitro assessment
Autor/es:
MARIO D. NINAGO; ANDRÉS E. CIOLINO; MARCELO A. VILLAR
Revista:
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS
Editorial:
TAYLOR & FRANCIS AS
Referencias:
Lugar: Londres; Año: 2020
ISSN:
0091-4037
Resumen:
Model PCL homopolymers (anionic polymerization) were synthetized and chemically functionalized with anhydrides to improve their bio-activity. Modified polyesters were used to fabricate highly porous PCL membranes by leaching technique, reaching porosities values up to 86.1%. Microstructural characterization revealed that chemical modification did not affect thermal properties and mechanical stabilities of PCL membranes. In vitro assays were carried out by soaking samples in simulated body fluid (SBF) solution. By SEM-EDX and TGA analyses, it was observed thatmodified polyesters exhibited a hydroxyapatite layer over polymeric surfaces, with calcium/phosphorous ratio of 1.58, close to the value reported by literature for hard tissue.
