Assembly of chitosan support matrix with gallic acid-functionalized nanoparticles

JAVIER LAMARRA; LEDA GIANUZZI; SANDRA RIVERO; ADRIANA PINOTTI

MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2017 vol. 79 p. 848 - 859

0928-4931

The incorporation of gallic acid (GA) in a direct way or into nanoparticles being included in chitosan edible films appears as a suitable approach to increase its preservation upon adverse conditions. This work was focused on: - synthesizing chitosan-based active supports by direct inclusion of gallic acid in the filmogenic solution or through of its nanoencapsulation with different CH:TPP ratios. - evaluating the influence of the GA inclusion strategy on the chitosan polymeric properties- comparing the controlled release of GA either incorporated directly in the chitosan matrix or loaded in the nanoparticles included in the polymeric support- assessing the influence of CH:TPP ratios, and therefore the nanoparticle diameters on the controlled release - using mathematical models describing the physical mechanisms to evaluate the transport properties of the active compound.It is worth noting that the addition of nanoparticles to chitosan-based matrices resulted in improvements of their swelling and solubility properties. By means of the nanoencapsulation the release process was modulated in relation to the delivery of GA included directly in a matrix, releasing the agent at a lower rate for a longer release time. Films containing functionalized nanoparticles are promising as a means to develop tailor-made support matrices for improving both the shelf stability of active compound included and final product quality. The results suggested that active films with nanoparticles could be a potential candidate for the support and controlled release of active compounds such as gallic acid in order to be used for packaging in food preservation.