Effect of corticosterone on metabolism balance in Passer domesticus.

PADRONES MN; BERDASCO, CLARA; CID, FD; CHEDIACK, JG; CAVIEDES-VIDAL E

San Luis

Congreso; Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2012

Sociedad de Biología de Cuyo

During fasting has been observed alterations in biochemical metabolites associated not only with food restriction, but also with variations of some hormones related with energy balance (i.e. insulin, glucagon, corticosterone). The objective was to determine the effect of corticosterone (CORT) on glucose (Glu) and triglycerides (TGL), as proxies of energy balance, and on uric acid (UA), total protein (TP) and heterophyl/lymphocyte index (H/L) as proxies of the physiological status of house sparrows. Two independent groups of 6 randomly chosen birds were exposed to either a high or low doses of CORT. In addition a basal and a DMSO (CORT vehicle) control groups were established. Blood samples of independent groups were collected at 0, 30 and 90 min to assay TGL, Glu, UA and TP. A multivariate ANOVA and a Tukey post-hoc test were performed to compare treatments. The high CORT group increased Glu level at 30 and 90 min, while effect on TGL was not homogenous, the high dose showed an increased and the low dose exhibited a decreased TGL level at time=30 min. On the other hand, CORT increased AU level and H/L index, but no effect was apparent on TP levels. These findings give support that CORT is involved in the regulation of metabolism balance. Supported by NSF 1025886 to ECV and WHK, by UNSL CyT 9502 and PIP N°0998 CONICET and CyT-UNSL 0110 to JGC.